Introducing MACI cartilage repair using your own cells

MACI uses your own cells to create durable repair tissue for knee cartilage
damage and can:

Reduce pain1,2

Improve function1,2

Provide lasting results2,3

How MACI Works

A sample of your cartilage cells (chondrocytes) is sent to a laboratory and embedded on a special collagen membrane which your doctor then implants into your knee. The cartilage cells regenerate, forming a repair tissue that is able to fill the cartilage defect.

From your cells to MACI:
A step-by-step guide

After MACI is implanted, you will begin a physician-prescribed rehabilitation program specifically designed for you.

MACI should not be used in patients who cannot follow a doctor-prescribed rehabilitation program after their surgery.

Learn more about rehabilitation


1. In the SUMMIT clinical trial, MACI was shown to offer greater pain relief and improvement in function when compared to microfracture.

2. Saris D, Price A, Widuchowski W, et al. Matrix-applied characterized autologous cultured chondrocytes versus microfracture: Two-year follow-up of a prospective randomized trial. Am J Sports Med. 2014;42(6):1384-94.

3. Improvements in pain and function were maintained with MACI at year 5.