Why MACI Skip to content

Why Choose MACI?

Because you don’t want to be sidelined.

Making the decision with your doctor to move forward with MACI can be overwhelming. It’s important to keep in mind that cartilage damage doesn’t heal on its own and can get worse over time.1 The sooner you and your doctor decide to move forward with the MACI procedure, the sooner your cells can start building durable repair tissue to help you get back to an active lifestyle. Need a little more inspiration?

Your cartilage will not heal on its own.

A study of patients undergoing cell-based knee cartilage restoration showed that as time increased between cartilage biopsy (arthroscopy) and implantation, many patients developed a new high-grade cartilage defect.1

Imagine life after MACI

Is your knee cartilage damage keeping you from the activities you’re used to?

Have you spoken with your doctor about your concerns and your limited activity?

Rehab is a commitment, but you’ve experienced difficult training challenges before.

What’s holding you back from the active lifestyle you deserve?

Want to know more about the MACI procedure?

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How you rehab after the procedure is so important in your return to living life on your terms.

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Looking for more details and inspiration to move forward with MACI? Take the next step.

Reference: 1. Pettit RJ, Everhart JS, DiBartola AC, Blackwell RE, Flanigan DC. Time Matters: Knee Cartilage Defect Expansion and High-Grade Lesion Formation while Awaiting Autologous Chondrocyte Implantation. Cartilage. 2021 Dec;13(2_suppl):1802S-1808S.

Indication and Important Safety Information

Important Safety Information

MACI should not be used if you:

  • are allergic to antibiotics such as gentamicin, or materials that come from cow, pig, or ox;
  • have severe osteoarthritis of the knee, other severe inflammatory conditions, infections or inflammation in the bone joint and other surrounding tissue, or blood clotting conditions;
  • have had knee surgery in the past 6 months, not including surgery for obtaining a cartilage biopsy or a surgical procedure to prepare your knee for a MACI implant;
  • or cannot follow a doctor-prescribed rehabilitation program after your surgery

Consult your doctor if you have cancer in the area of the cartilage biopsy or implant as the safety of MACI is not known in those cases.

Conditions that existed before your surgery, including meniscus tears, joint or ligament instability, or alignment problems should be evaluated and treated before or at the same time as the MACI implant.

MACI is not recommended if you are pregnant.

MACI has not been studied in patients younger than 18 or over 55 years of age.

Common side effects include joint pain, tendonitis, back pain, joint swelling, and joint effusion.

More serious side effects include joint pain, cartilage or meniscus injury, treatment failure, and osteoarthritis.

Please see Full Prescribing Information for more information.


MACI® is made up of your own (autologous) cells that are expanded and placed onto a film that is implanted into the area of the cartilage damage and absorbed back into your own tissue.

MACI® (autologous cultured chondrocytes on porcine collagen membrane) is made up of your own (autologous) cells that are expanded and placed onto a film that is implanted into the area of the cartilage damage and absorbed back into your own tissue.

MACI is used for the repair of symptomatic cartilage damage of the adult knee.

The amount of MACI applied depends on the size of the cartilage damage. The MACI film is trimmed by your surgeon to match the size and shape of the damage, to ensure the damaged area is completely covered.

Limitations of Use

It is not known whether MACI is effective in joints other than the knee.

It is not known whether MACI is safe or effective in patients over the age of 55 years.