REHABILITATION TIMELINE
FOLLOWING a MACI procedure

Following the MACI procedure, your knee will be immobilized and you will need to follow a physician-prescribed rehabilitation program specifically designed for you. Consult with your doctor to determine when you might be able to drive and return to work or other activities.

A support program is available to assist with a smooth recovery. The commitment you make to the rehabilitation program will play a key role in your return to activity. Recovery time varies greatly as no two patients are alike. Below are general guidelines for typical patient recovery.^1*

MACI should not be used in patients who cannot follow a doctor-prescribed rehabilitation program after their surgery.

* Individual results may vary

Phase 1 of 7:0-1 week following surgery

Immediate post-op

Goals: Maintain joint mobility and muscle tone, weight-bearing <20%

Phase 2 of 7:2-3 weeks following surgery

restore mobility

Goals: Pain-free and full passive knee extension; limited weight bearing; continue to manage pain, swelling, and wound care

Phase 3 of 7:4-6 weeks following surgery

strengthen & straighten

Goals: Independent with crutches for activities of daily living; pain-free active knee flexion to 125°; independent in performing home exercises

Phase 4 of 7:7-12 weeks following surgery

independent movement

Goals: Work toward movement free of ambulation devices and knee braces, independent with rehabilitation exercises

Phase 5 of 7:3-6 months following surgery

return to daily activity

Goals: Return to strenuous daily activities on a limited basis; unimpeded, pain-free movement through everyday environments, including stairs

Phase 6 of 7:6-9 months following surgery

recreational activities

Goals: Returns to low-impact recreational activities by gradually increasing the difficulty of exercises

Phase 7 of 7:9-12 months following surgery

return to full activity

Goals: A full return to recreational activities, working toward individual goals as the implant matures

After a cartilage biopsy, learn about MACI Patient Support here

1. Jay Ebert, PhD, AEP ESSAM. MACI (autologous cultured chondrocytes on porcine collagen membrane) Rehabilitation Manual. October, 2018

Indication

MACI^® (autologous cultured chondrocytes on porcine collagen membrane) is made up of your own (autologous) cells that are expanded and placed onto a film that is implanted into the area of the cartilage damage and absorbed back into your own tissue.

MACI is used for the repair of symptomatic cartilage damage of the adult knee.

The amount of MACI applied depends on the size of the cartilage damage. The MACI film is trimmed by your surgeon to match the size and shape of the damage, to ensure the damaged area is completely covered.

Limitations of Use

It is not known whether MACI is effective in joints other than the knee.

It is not known whether MACI is safe or effective in patients over the age of 55 years.

Important safety information

MACI should not be used if you:

are allergic to antibiotics such as gentamicin, or materials that come from cow, pig, or ox;
have severe osteoarthritis of the knee, other severe inflammatory conditions, infections or inflammation in the bone joint and other surrounding tissue, or blood clotting conditions;
have had knee surgery in the past 6 months, not including surgery for obtaining a cartilage biopsy or a surgical procedure to prepare your knee for a MACI implant;
or cannot follow a doctor-prescribed rehabilitation program after your surgery

Consult your doctor if you have cancer in the area of the cartilage biopsy or implant as the safety of MACI is not known in those cases.

Conditions that existed before your surgery, including meniscus tears, joint or ligament instability, or alignment problems should be evaluated and treated before or at the same time as the MACI implant.

MACI is not recommended if you are pregnant.

MACI has not been studied in patients younger than 18 or over 55 years of age.

Common side effects include joint pain, tendonitis, back pain, joint swelling, and joint effusion.

More serious side effects include joint pain, cartilage or meniscus injury, treatment failure, and osteoarthritis.

Please see Full Prescribing Information for more information.

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