A step-by-step guide to the MACI process

Biopsy taken

Step 1: Biopsy taken

If your doctor thinks MACI may be an option for you at some point, he or she will take a biopsy (a sample of tissue approximately the size of two Tic Tacs®) of your healthy knee cartilage.

Tic Tac is a registered trademark of Ferrero S.p.A

Biopsy processed

Step 2: Biopsy processed

The biopsy is shipped to a state-of-the-art, quality-controlled, FDA-licensed facility in Cambridge Massachusetts, where it will be stored cryogenically (frozen) for you.

Your own cells

Step 3: Your own cells

When you and your doctor decide the time is right for MACI, cartilage cells (chondrocytes) from your biopsy will be expanded and seeded on a special membrane.

MACI delivered

Step 4: MACI delivered

MACI is delivered to your surgeon for the implantation procedure.

MACI implanted

Step 5: MACI Implanted

Your surgeon will shape the MACI implant to the size of your particular cartilage defect and then place it into your knee, affixing it to the damaged area.

Rehabilitation is the final step

After MACI is implanted, you will begin a physician-prescribed rehabilitation program specifically designed for you.

MACI should not be used in patients who cannot follow a doctor-prescribed rehabilitation program after their surgery.