MACI Arthro™
Important Safety Information
Full Prescribing Information
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Are You a Candidate for the Arthroscopic Delivery of MACI?

Ask your doctor for more information

Arthroscopic delivery of MACI is approved for accessible lesions up to 4cm2. Depending on your defect location and size, your doctor has options for MACI implant delivery.

See How MACI Arthro™ Works

How MACI Works

If your doctor has identified you as a candidate for MACI, your doctor may have performed an arthroscopic procedure to help examine and diagnose your knee cartilage damage. The sample of your cartilage cells is used to grow new cells for your MACI implant. These new cells will then create durable repair tissue for your damaged knee cartilage.

This can help:

Reduce Pain*1

Improve function*1

Provide lasting results†1

* In the SUMMIT clinical trial, MACI was shown to offer greater pain relief and improvement in function when compared to microfracture.
† Improvements in pain and function were maintained with MACI at year 5.

Mini Arthrotomy Delivery

Mini Arthrotomy Delivery

Arthroscopic Delivery

Arthroscopic Delivery

Arthroscopic Delivery of MACI

Your doctor may deliver MACI through a mini arthrotomy or through an arthroscopy. If you are a candidate for the minimally invasive arthroscopic delivery of MACI, your doctor will:

  • Use a camera through an incision to examine your knee
  • Make appropriate incision(s) as needed to deliver the MACI implant.

Arthroscopic delivery of MACI incorporates the advantages of an arthroscopic approach with the long-term durability and established results of MACI. When delivered arthroscopically, MACI knee cartilage repair offers a less invasive surgical incision than knee cartilage treatment options via standard arthrotomy.2 Individual results may vary.

Talk to your doctor to see if you are a candidate for arthroscopic delivery of MACI.

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Reference: 1. Saris D, Price A, Widuchowski W et al. Matrix-Applied Characterized Autologous Cultured Chondrocytes Versus Microfracture. Am J Sports Med. 2014;42(6):1384-1394. i:10.1177/0363546514528093 2. Edwards PK, Ebert JR, Janes GC, Wood D, Fallon M, Ackland T. Arthroscopic versus open matrix-induced autologous chondrocyte implantation: results and implications for rehabilitation. J Sport Rehabil. 2014;23(3):203-215. doi:10.1123/jsr.2013-0042.

Indication and Important Safety Information

Important Safety Information

MACI should not be used if you:

  • are allergic to antibiotics such as gentamicin, or materials that come from cow, pig, or ox;
  • have severe osteoarthritis of the knee, other severe inflammatory conditions, infections or inflammation in the bone joint and other surrounding tissue, or blood clotting conditions;
  • have had knee surgery in the past 6 months, not including surgery for obtaining a cartilage biopsy or a surgical procedure to prepare your knee for a MACI implant;
  • or cannot follow a doctor-prescribed rehabilitation program after your surgery

Consult your doctor if you have cancer in the area of the cartilage biopsy or implant as the safety of MACI is not known in those cases.

Conditions that existed before your surgery, including meniscus tears, joint or ligament instability, or alignment problems should be evaluated and treated before or at the same time as the MACI implant.

MACI is not recommended if you are pregnant.

MACI has not been studied in patients younger than 18 or over 55 years of age.

Common side effects include joint pain, tendonitis, back pain, joint swelling, and joint effusion.

More serious side effects include joint pain, cartilage or meniscus injury, treatment failure, and osteoarthritis.

Please see Full Prescribing Information for more information.

Indication

MACI® is made up of your own (autologous) cells that are expanded and placed onto a film that is implanted into the area of the cartilage damage and absorbed back into your own tissue.

MACI® (autologous cultured chondrocytes on porcine collagen membrane) is made up of your own (autologous) cells that are expanded and placed onto a film that is implanted into the area of the cartilage damage and absorbed back into your own tissue.

MACI is used for the repair of symptomatic cartilage damage of the adult knee.

The amount of MACI applied depends on the size of the cartilage damage. The MACI film is trimmed by your surgeon to match the size and shape of the damage, to ensure the damaged area is completely covered.

Limitations of Use

It is not known whether MACI is effective in joints other than the knee.

It is not known whether MACI is safe or effective in patients over the age of 55 years.