How MACI works
The process begins with a minimally invasive biopsy, called an arthroscopy procedure, to procure a sample of your cartilage cells (chondrocytes). This sample is then sent to a laboratory and allowed a period of time to grow.
During a second minimally invasive procedure, your cartilage cell sample will be embedded on a special collagen membrane, then implanted into your knee by your MACI specialist.
Watch how this works
From your cells to MACI: A step-by-step guide
When knee cartilage is damaged—from an injury or daily wear and tear—it cannot function properly, and doesn’t heal on its own. This means your cartilage injury could get worse over time, leaving you with more pain and limiting your physical activity.
MACI uses your own cells to repair your knee cartilage damage.
During your arthroscopy, a procedure to look inside your knee, your surgeon will take 2 to 3 pieces of healthy knee cartilage—each about the size of a Tic Tac®—and send them to our state-of-the-art, FDA-licensed facility.
At the facility, your cartilage cells will be treated to help them expand and multiply.
Your expanded cells are then placed onto a special membrane and delivered to your surgeon for your procedure.
The membrane will be customized to match the size and shape of your cartilage defect before it is affixed to the damaged area of your knee cartilage.
Once implanted into the damaged area, your cells detach from the membrane, combine with proteins in your knee cartilage, and form a durable repair tissue.
This durable repair tissue continues to mature over time, filling your defect to regenerate the damaged cartilage.
You will begin a physician-prescribed rehabilitation program specifically designed for you.
As you progress through the program, you should begin to experience restored knee function, helping you get back to your active lifestyle.
Talk with real patients about their experience with MACI
Hear about real personal experiences with knee cartilage damage and MACI. The MACI Mentor Program gives you an opportunity to connect one-on-one with real people who have had the MACI procedure.
“My MACI procedure had a positive impact on my ability to participate in daily activities. I can now spend long hours on my feet at work with confidence, and I’m back to enjoying the activities I love.”
—Kayla, MACI patient
Individual results may vary
See Kayla’s and others’ stories about how MACI has helped them get back to their active way of life.
* In the SUMMIT clinical trial, MACI was shown to offer greater pain relief and improvement in function when compared to microfracture.
† Improvements in pain and function were maintained with MACI at year 5
Reference: 1. Saris D, Price A, Widuchowski W et al. Matrix-Applied Characterized Autologous Cultured Chondrocytes Versus Microfracture. Am J Sports Med. 2014;42(6):1384-1394. doi:10.1177/0363546514528093