A step-by-step guide to the MACI procedure

Biopsy Taken

Step 1: Biopsy taken

A small biopsy of healthy cartilage is taken arthroscopically from a non weight-bearing area of the patient’s knee.

Typical harvest sites include the intercondylar notch and the proximal aspect of the medial and/or lateral femoral condyle.

Biopsy Processed

Step 2: Biopsy processed

The biopsy is sent to the Vericel cell-processing facility in Cambridge Massachusetts.

A state-of-the-art cell-processing facility provides optimal product quality and safety.

Chondrocytes Extracted and Loaded

Step 3: Chondrocytes extracted and loaded

Chondrocytes are extracted from the biopsy, expanded, and, using proprietary methods are uniformly seeded onto a resorbable Type I/III collagen membrane.

MACI delivers a controlled, uniform dose of cells with a density of at least 500,000 per cm² on a Type I/III collagen membrane.

MACI Delivered

Step 4: MACI delivered

MACI is delivered via courier to the treatment facility for the procedure.

Defect Debrided

Step 5: defect debrided

The defect area is debrided back to healthy, stable cartilage.

Template Created

Step 6: template created

To ensure precise sizing, use sterile materials to create a template of the defect.

MACI implanted

Step 7: maci implanted

The MACI implant is secured in place using fibrin sealant. Suture fixation is not required.

The MACI implant can be easily cut and shaped to the appropriate size.

Rehabilitation is the final step

Patients who receive the MACI implant must follow a physician-prescribed rehabilitation program. Patients should begin rehabilitation within hours after treatment. Consult the MACI Rehabilitation Guidelines for specific instructions.

MACI is contraindicated in patients who are unable to follow a physician-prescribed post-surgical rehabilitation program.


How long does MACI take, from biopsy to normal ambulation? Read on to find out