MACI is appropriate for a wide range of knee cartilage defects

Who is a candidate for MACI?

MACI is approved for the repair of single or multiple symptomatic, full-thickness cartilage defects of the knee (with or without bone involvement) in adults aged 18-55. The MACI implant measures 5cm x 3cm and is cut and shaped by the surgeon to the appropriate size of the cartilage defect(s).

MACI is an appropriate option for the defects described below:

LATERAL FEMORAL CONDYLE (LFC)

Patient:

Female, 44

Defect:

1 cm x 2.2 cm (2.2 cm2)

MEDIAL FEMORAL CONDYLE (MFC) with bone involvement

Patient:

Male, 45

Defect:

3 cm x 3 cm (9 cm2)

MEDIAL FEMORAL CONDYLE (MFC)

Patient:

Male, 19

Defect:

2.5 cm x 2.5 cm (6.25 cm2)

PATELLA

Patient:

Male, 32

Defect:

2.5 cm x 2 cm (5 cm2)

TROCHLEA

Patient:

Male, 25

Defect:

3 cm x 2 cm (6 cm2)

In a retrospective of the first 1,000 U.S. MACI patients, a variety of defect locations for single defect surgeries with MACI were shown:

Defect Locations

Use of MACI (Autologous Cultured Chondrocytes on Porcine Collagen Membrane) in the United States—Preliminary Experience.

James L. Carey, MD, MPH, Ann E. Remmers, PhD, and David C. Flanigan,MD

The Orthopaedic Journal of Sports Medicine [Internet]. 2020 August;8(8):1-7.